P62 - AN OVERVIEW

Oxidative tension triggers DNA problems within the nucleus and mitochondria. DNA fragments are then launched into the cytoplasm, the place they induce p62-mediated selective autophagy by distinct mechanisms plus the cGAS-STING-mediated DNA sensing innate immune pathway. The kinases ULK1 and TBK1 Engage in twin roles in these two pathways. ULK1 phos